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Huntington’s disease (HD) is at the center of one of the most remarkable stories of discovery in medical history.

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In George Huntington, a North American general practitioner, published the first unambiguous description of the unrelenting neurodegenerative disorder in The Medical and Surgical Reporter. The title of his article was simply “On Chorea” referring to the strange involuntary contorted movements made by people with HD.

His description of this type of chorea as a specific hereditary disorder became quickly and widely accepted. Careful pedigrees of generations of HD families around the world have since confirmed his theory by documenting that 50% of the children of a parent with HD, will develop HD if they live long enough.

That is, HD is an autosomal dominant hereditary disorder.

Simply put, HD is caused when one gene (or allele) of a usually healthy gene pair we all carry is abnormally elongated. This HD gene mutation is domina